Uji aktivitas anti diabetes flakes tepung jantung pisang kepok kuning (musa paradisiaca linn.) pada mencit yang terinduksi streptozotocin
Fanesa Presilia(1)
Andriani Noerlita Ningrum(2*)
Yesi Ihdina Fityatal Hasanah(3) (1) Mahasiswa Program Sarjana Farmasi, STIKELS Mamba’ul ‘Ulum Surakarta, Indonesia
(2) Doseln Program Studi Sarjana Farmasi, STIKELS Mamba’ul ‘Ulum Surakarta, Indonesia
(3) Dosen Program Studi Tasawuf dan Psikoterapi, Fakultas Ushuluddin dan Dakwah, UIN Raden Mas Said Surakarta, Indonesia
(*) Corresponding Author
Abstract
Latar beakang: Diabetes melitus merupakan penyakit metabolik kronis yang memerlukan pendekatan pengelolaan yang aman dan berkelanjutan. Jantung pisang kepok kuning (Musa paradisiaca Linn.) mengandung senyawa bioaktif yang berpotensi dikembangkan sebagai pangan fungsional antidiabetes. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi kandungan fitokimia serta mengevaluasi aktivitas antidiabetes flakes tepung jantung pisang kepok kuning pada mencit yang diinduksi streptozotocin. Metode: Penelitian eksperimental in vivo dilakukan menggunakan mencit jantan yang dibagi menjadi kelompok kontrol normal, kontrol negatif (Na-CMC), kontrol positif (glibenklamid), serta kelompok perlakuan flakes dengan konsentrasi 12,5%, 25%, dan 50%. Induksi diabetes dilakukan menggunakan streptozotocin. Parameter yang diamati meliputi skrining fitokimia dan perubahan kadar glukosa darah selama 14 hari. Data dianalisis secara deskriptif kuantitatif. Hasil: Skrining fitokimia menunjukkan bahwa tepung dan flakes jantung pisang mengandung flavonoid, tanin/saponin, kumarin, dan senyawa fenolik. Secara deskriptif, pemberian flakes tepung jantung pisang menunjukkan penurunan kadar glukosa darah pada mencit terinduksi streptozotocin, dengan kecenderungan efek yang lebih baik pada konsentrasi 25% dan 50%. Simpulan: Flakes tepung jantung pisang kepok kuning berpotensi sebagai pangan fungsional pendukung dalam pengelolaan diabetes melitus.
Keywords
Full Text:
PDFReferences
American Diabetes Association. (2024). Pharmacologic Approaches to Glycemic Treatment : Standards of Care in Diabetes — 2024. In Diabetes Care (Vol. 47, Issue January).
Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., & Green, J. (2022). Management of hyperglycaemia in type 2 diabetes , 2022 . A consensus report by the American Diabetes Association ( ADA ) and the ELuropean Association for the Study of Diabetes ( ELASD ). Diabetologia, 65, 1925–1966.
Furman, B. L. (2021). Streptozotocin-Induced Diabetic Models in Mice and Rats. Current Protocols, 1(e78), 1–21. https://doi.org/10.1002/cpz1.78
Galaniha, L. T., Mcclements, D. J., & Nolden, A. (2020). Opportunities to improve oral nutritional supplements for managing malnutrition in cancer patients : A food design approach. Trends in Food Science & Technology, 102(August), 254–260.
Go, G., Lee, H., Jeon, J., Lee, G., & Lee, J. H. (2021). Bovine milk extracellular vesicles induce the proliferation and differentiation of osteoblasts and promote osteogenesis in rats. Journal of Food Science, 45(4), 1–11. https://doi.org/10.1111/jfbc.13705
Kwok, J. J. N., Chen, M. K., & Ong, C. W. (2025). Antidiabetic Potential of Bananas ( Musa spp . ): A Systematic Review of Bioactive Compounds and Antihyperglycemic Activities. Current Nutrition Reports, 14(38), 1–14.
Leit, C., Mignano, A., ELstrela, M., Fardilha, M., Figueiras, A., Roque, F., & Herdeiro, M. T. (2022). The ELffect of Nutrition on Aging — A Systematic Review Focusing on Aging-Related Biomarkers. Nutrients, 14(554), 1–29.
Malecki, M., Batterham, R., Sattar, N., Levine, J., Rodriguez, A., Bergman, B., Wang, H., Ghimpeteanu, G., & Lee, C. (2023). IDF2022-0369 Predictors of achieving weight loss ≥15% with tirzepatide in people with type 2 diabetes from SURPASS 1-4. Diabetes Research and Clinical Practice, 197. https://doi.org/https://doi.org/10.1016/j.diabres.2023.110271
Mao, T., Huang, F., Zhu, X., Wei, D., & Chen, L. (2021). ELffects of dietary fiber on glycemic control and insulin sensitivity in patients with type 2 diabetes : A systematic review and meta-analysis. Journal of Functional Foods, 82, 104500.
Michalska-ciechanowska, A., Masztalerz, K., Mangieri, N., Foschino, R., Lech, K., Wojdy, A., Nowicka, P., & Brzezowska, J. (2024). Unlocking the potential of oil by-products : Investigating the influence of co-culture fermentation on phenolic acid degradation in side stream blends from oil and dairy industry. Future Foods, 9(February). https://doi.org/10.1016/j.fufo.2024.100324
Muirhead, R., Kizirian, N., Lal, R., Black, K., Prys-davies, A., Nassar, N., Baur, L., Sainsbury, A., Sweeting, A., Markovic, T., & Skilton, M. (2021). A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity. Nutrien, 13.
Ningrum, A. ., Widyaningrum, N. ., & Sulistyorini, EL. (2021). A LITELRATUREL RELVIELW : PELNGARUH PELRBELDAAN PELLARUT ELKSTRAK JANTUNG PISANG (Musa paradisiaca) SELBAGAI GALAKTOGOGUM. Avicenna : Journal of Health Research, 4(1), 81–89.
Rafi, A., Yaningsih, T., Rahmadhia, S. N., Pangan, T., & Dahlan, U. A. (2023). Karakteristik fisik dan kimia flakes tepung kelopak jantung pisang kepok kuning ( Musa paradisiaca Linn ). Agrointek, 17(2), 280–287. https://doi.org/10.21107/agrointek.v17i2.11619
Sarma, P., Madhavan, A., Soumya, R. S., & Arun, K. B. (2025). Pharmacological Insights into Banana Inflorescence - A Review of Antioxidant, Antimicrobial, Antidiabetic, and Anticancer Potential. International Journal of Pharmaceutical Science, 3(9), 242–253. https://doi.org/10.5281/zenodo.17038267
Schwartz, G. G., Leiter, L. A., Ballantyne, C. M., Barter, P. J., Black, D. M., Kallend, D., Fouzia Laghrissi-Thode, Leitersdorf, EL., McMurray, John J.V. Nicholls, Stephen J. Olsson, A. G., Preiss, D., Shah, P. K., Tardif, J.-C., & Kittelson, J. (2020). Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease. Diabetes Care, 43(5), 1077–1085.
Senevirathna, N., & Karim, A. (2024). Banana inflorescence as a new source of bioactive and pharmacological ingredients for food industry. Food Chemistry Advances, 5(2), 1–21. https://doi.org/https://doi.org/10.1016/j.focha.2024.100814
Vilhena, R. D. O., Fachi, M. M., Marson, B. M., Pontes, L. D., Tonin, F. S., & Pontarolo, R. (2018). Antidiabetic potential of Musa spp . inflorescence : a systematic review. Journal of Pharmacy and Pharmacology, 70, 1583–1595. https://doi.org/10.1111/jphp.13020
Wang, Y., & Zhang, G. (2021). The preparation of modified nano-starch and its application in food industry. 140(February), 1–8.
WHO. (2023). Diabetes. https://doi.org/10.1016/j.diabres.2023.110271
DOI: https://doi.org/10.36419/avicenna.v9i1.1752
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Avicenna : Journal of Health is published by Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta.
Jl. Ring Road No.Km 03, Mojosongo, Kec. Jebres, Kota Surakarta, Jawa Tengah 57127 | email : info@stikesmus.ac.id | web : www.stikesmus.ac.id
Avicenna : Journal of Health is licensed under a Lisensi Creative Commons Atribusi-BerbagiSerupa 4.0 Internasional |